Why is "validation" important?
Stalls are very rare in Alzheimer's brain, but each is extremely important. Stalls - clogged blood vessels - reduce blood flow to many downstream vessels in the brain, sometimes costing up to 30% of total blood flow.
That way, stalls could influence many processes in the brain, including clearance of amyloid beta - the peptide responsible for toxic plaque formation in Alzheimer's-affected brain.
Read more about the science behind Stall Catchers here.
Figuring out where they stalls are and why do they occur will help us to get closer to reducing and preventing them, which could for the first time help us treat Alzheimer's.
We need to make sure we are not missing any stalls!
Pooling crowd answers will help us make sure we don't accidentally miss any stalls, or produce too many false positives. And we'd like to know how many answers is enough, so we don't keep you all annotating the same vessels over and over again!
(For example, in Malaria Spot the magic number has been found to be 22. The historic Galaxy Zoo first study gathered on average 38 classifications per galaxy.)
We are using the Validation study to get the magic number for Stall Catchers. :)
After we complete the validation we will start uploading more real data into the game & start answering research questions that have not been possible to study until now due to the extremely time-consuming data annotation step.
We need YOUR help to get there faster! The sooner we complete this, the sooner we can start doing real Alzheimer's research.