Finally, more data in Stall Catchers - and it's continuing the NOX2 saga.
(Read the backstory of NOX2 here: https://blog.hcinst.org/nox-vol2/
In this set, we are analyzing the effects of NOX2 inhibition, similarly as before, but on a different mouse model of Alzheimer's disease - meaning Alzheimer's has been triggered in the mice in a different way. This model, called 5XFAD, uses a different genetic modification to drive the pathology of Alzheimer's in mice. The goal is to rule out any idiosyncratic effects in a particular mouse model of Alzheimer's. Slow and careful!
And here's why the researchers are interested in the NOX2 pathway in relation to capillary stalls and Alzheimer's disease: